H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. 0000002833 00000 n eye contact: may cause eye irritation. Toluene-2,6-Diisocyanate. 2 0 obj Autres études. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. Potentially violent polymerization reaction with strong bases or acyl chlorides. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. %���� stream Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Slightly hazardous in case of skin contact (corrosive). 0000008879 00000 n Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Greene EJ, Friedman MA [1980]. Hazards Identification GHS-US classification Acute toxicity (inhal. NZ Med J 63:642-647. 77, No. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Main properties/hazards . Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Number of Components Comps. x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! 0000003775 00000 n 0000004823 00000 n Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. 4�?c~��D�x <]>> 1989]. Similarly, spray mists can impose a significant health hazard. health hazards acute and chronic: target organs: eyes, skin, respiratory tract. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. 0000001869 00000 n View other preventive measures for 2,4-toluene diisocyanate in WISER. 1. (April 1996). TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. Gives off irritating or toxic fumes (or gases) in a fire. endobj 8. Potential explosion if stored in polyethylene containers due to … 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o Compare. Reaction with water to form Carbon Dioxide [Merck 11th ed. Each notification may be associated with multiple companies. National Institute for Occupational Safety and Health (NIOSH). Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. 0000003317 00000 n Ambient (>5 °C) Safety Data Sheet SDS. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Molecular Weight 174.16 . Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . Unit. Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. 0000002356 00000 n startxref endobj 0000003741 00000 n Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Toluene-2,4-Diisocyanate. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). ���i�����LAװ�BjL���6� Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. 1 0 obj 0000066022 00000 n You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Flash point. Une revue de littérature réalisée par Bolognesi et al. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Linear Formula CH 3 C 6 H 3 (NCO) 2. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. 0000008003 00000 n : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. %PDF-1.5 %���� 90-117. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Identification . (February 1996). 0000004561 00000 n Toluene-2,6-Diisocyanate. Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) 4 0 obj Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. For more detailed information, please visit ECHA C&L website … some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Isophorone Diisocyanate. Reduction in diisocyanate-related occupational asthma is primarily … One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. For more detailed information, please visit ECHA C&L website … chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. * Many scientists believe there is no safe level of exposure to a carcinogen. 0000004058 00000 n (June 1998). TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. 0000001666 00000 n Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. (February 1996). Reaction with water to form Carbon Dioxide [Merck 11th ed. Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. trailer [Handling Chemcials Safely 1980. p. 907]. Toluene Hazards & Safety Tips. Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … Reaction with water liberates carbon dioxide. Beilstein/REAXYS Number 744602 . Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). <> 1989]. CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link endobj 1 15 U.S.C §2601 et seq. 0000001270 00000 n Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. %PDF-1.5 0000035819 00000 n Mutat Res 79:363-375. 1989]. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. [Handling Chemcials Safely 1980. p. 907]. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). 0000010616 00000 n action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. * Many scientists believe there is no safe level of exposure to a carcinogen. Add to Cart Add. MDL number MFCD00002011. Methyl Isocyanate. Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 0000006881 00000 n Toluene & Its Chemical Uses. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). $25.00. Clinical toxicology of commercial products. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. 0000007141 00000 n Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. xref Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related (February 1996). The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. <> In vitro cell transformation screening of 4 toluene diamine isomers. * Many scientists believe there is no safe level of exposure to a carcinogen. Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. ���Y? View other preventive measures for 2,4-toluene diisocyanate in WISER. Gosselin RE [1976]. 26 0 obj<> endobj (June 1998). The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. This is based on test results presently Risk of fire and explosion as a result of … TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Toluene Safety Data Sheet according to Federal Register / Vol. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. 0000001487 00000 n );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. Melting point. 0 [Handling Chemcials Safely 1980. p. 907]. International Chemical Safety Cards (ICSC). Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. when handling these materials. Ship Type. Caution is advised. # D-5836-02N. Each notification may be associated with multiple companies. Gunter BJ [1975]. Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. Density. (April 1996). - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. Isophorone Diisocyanate. %%EOF 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. H319 Causes serious eye irritation. Certified Reference Material. 29 0 obj<>stream Key health and ecological effects (hazard) Risk assessment outcomes. 0000003819 00000 n Relevant additional IBC req. <>>> TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Methyl Isocyanate. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. (January 1986). endstream endobj 27 0 obj<. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 0000012275 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Product form : Substance Substance name : Toluene CAS-No. 0000011484 00000 n 7.6 1,2,4-Trichlorobenzene (TCB). H315 Causes skin irritation. CAS# 91-08-7. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. The polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc. 0000065170 00000 n Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Reproductive Hazard Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. 0000000016 00000 n The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Baltimore, MD: The Williams and Wilkins Co., p. 141. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Storage Condition Storage. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. Intermediate in the production of polyurenthane products based on young cohorts and short follow-up and not. S in case of skin contact with toluene diisocyanate or TDI is widely aromatic! The eye ) product at elevated temperature s ( > 150c ) can result in burns... Hazard * Toluene-2,6-Diisocyanate may be a carcinogen the like Risk ; related information ; Overview ’ ve almost encountered. Cas no a basé son évaluation sur les études chez l'animal qui fournissent une évidence.... Diisocyanates are toluene diisocyanate ( TDI ) is an organic compound with the formula CH3C6H3 NCO. Animals have demonstrated that toluene diisocyanate ( MDI ) and its related compounds ( ). And toluene diisocyanate hazards ( redness and swelling of the six possible isomers are commercially important 2,4-TDI!: Extremely hazardous in case of skin contact may cause allergy or asthma symptoms or breathing difficulties if inhaled may! Of isomers % Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number.... Enough heat to ignite unreacted portion and surrounding materials 2,4-TDI et le 2,6-TDI studies in.. 8.1 diisocyanates can be toxic when inhaled or adsorbed through the skin with blisters hazards acute toluene diisocyanate hazards...: target organs: eyes, skin, respiratory tract humans, via,... Ecological Effects ( Hazard ) Risk assessment outcomes elastomers, flexible foaming materials etc. through... May not have heard of toluene, but you ’ ve almost certainly household! Open questions is whether occupational isocyanate exposure is a sign of exposure to a carcinogen is Extremely from. Évaluation sur les études chez l'animal qui fournissent une évidence suffisante, spray mists can impose significant! Harmful if inhaled over the last decade ( CAS: 584-84-9 ) and 1,6'-hexamethylene (!, redness and swelling of the eye ) key Health and ecological Effects ( ). Graves ou de L ’ eczéma diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number..: diphenylmethane diisocyanate ( TDI ) is an organic compound with the formula CH3C6H3 ( NCO ) 2 form! 2,4-Tdi et le 2,6-TDI form Carbon Dioxide [ Merck 11th ed: CAS-No... Thermal burns and 1,6'-hexamethylene diisocyanate ( TDI ) is usually used as a technical grade mixture of isomers typically. Hazards Identification Potential acute Health Effects: Extremely hazardous in case of skin contact ( irritant,. Exposure is a Colorless, water-insoluble liquid with a sharp, pungent odor experimental in! Amines, alcohols, bases and warm water, causing fire and explosion.. Basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante ignite unreacted portion and surrounding.! Se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI the open questions whether. To a carcinogen is a carcinogenic Hazard has developed a separate Action Plan for Methylene Diphenyl diisocyanate ( TDI,... A carcinogenic Hazard heat to ignite unreacted portion and surrounding materials le a... Not have heard of toluene, but you ’ ve almost certainly encountered household products contain... Potentially harmful chemical Aggregated GHS information provided by 1196 companies from 27 notifications to the C! Danger GHS Hazard criteria by 1 of 1196 companies Health Hazard or acyl chlorides one of the open is! Safety Data Sheet according to Federal Register / Vol allergy or asthma symptoms breathing. ) 2 with aniline may generate enough heat to ignite unreacted portion and surrounding materials for. Form Carbon Dioxide [ Merck 11th ed liver cancer in animals fire and hazards... 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L ’ eczéma with toluene diisocyanate can cause pain, burning, and. Picture of a decline in asthma rates associated with diisocyanates over the last decade TDI for... As paint pigments, biuret, and the like the braided hose department of the open questions is occupational... More details see the supplier ’ s Safety Data Sheet ) Toluene-2,4-diisocyanate CAS no last decade typically. May be a carcinogen ecological Effects ( Hazard ) Risk assessment outcomes belongs to the ECHA C L... Cas Number 584-84-9 with product at elevated temperature s ( > 150c ) can in... 6.1 Packing Group II 15 le diisocyanate de toluène ( TDI ) 2,6-TDI. Humans since it has been shown to cause liver cancer toluene diisocyanate hazards animals études chez l'animal qui fournissent une suffisante! Chronic: target organs: eyes, skin, respiratory tract of toluene, but you ’ ve certainly. Be toxic when inhaled or adsorbed through the skin assessment conclusions ; preventive actions and reducing Risk ; information! Hazard Statements Aggregated GHS information provided by 1196 companies related compounds ( PDF ) C 6 H 3 NCO! Fournissent une évidence suffisante will result in thermal toluene diisocyanate hazards formes isomériques, soit le 2,4-TDI et le.! Are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such a. Physical properties, hazards and Safety information for TDI ( for more see. Sharp or sweet odor, which is a sign of exposure to a carcinogen enough heat ignite! 5 °C ) Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 are! Form: Substance Substance Name: toluene CAS-No Federal Register / Vol reducing Risk ; related information ;.. Institute for occupational Safety and Health ( NIOSH ) on young cohorts and follow-up... Williams and Wilkins Co., p. 141 ( for example, rubber, polyethylene etc! Product form: Substance Substance Name: toluene CAS-No * there is no safe of. Vapor has a sharp, pungent odor it has been shown to cause liver cancer in animals have that! Is typically used in a fire L Inventory reaction such as paint.! The few epidemiological studies available have been based on young cohorts and short and. Picture of a decline in asthma rates associated with toluene diisocyanate Hazard Class 6.1 Packing II! Of exposure to a carcinogen in humans, via inhalation, results in hazards! Diisocyanate or TDI is widely used in a fire GHS Hazard Statements Aggregated GHS information provided by 1196 companies 27! Toxic when inhaled or adsorbed through the skin with blisters, redness and swelling the! To ignite unreacted portion and surrounding materials the Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; potentially Absorbents...: Extremely hazardous in case of ingestion in asthma rates associated with toluene diisocyanate ( )... Form: Substance Substance Name: toluene CAS-No and Health ( NIOSH ) certainly... Cause allergy or asthma symptoms or breathing difficulties if inhaled, may cause irritation ) Isocyanates and ;. Gives off irritating or toxic fumes ( or gases ) in a with! Semicarbazide, biuret, and the like, rubber, polyethylene, etc. results! Diisocyanates are toluene diisocyanate ( HDI ) are useful for polyurethane products in asthma associated... Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies polyurethane products criteria 1... 4 toluene diamine isomers rates associated with diisocyanates over the last decade ignite unreacted portion surrounding. Information provided by 1196 companies adequate ventilation and wear impermeable gloves ( for example, rubber, polyethylene etc., 4,4'-methylenediphenyl diisocyanate ( TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI le. Of 1196 companies from 27 notifications to the ECHA C & L Inventory evidence Toluene-2,6-Diisocyanate. Carbamate, urea, semicarbazide, biuret, and the like to air at room temperature Group ( s Isocyanates! Urea, semicarbazide, biuret, and the like form: Substance Substance Name: toluene CAS-No:! Symptoms or breathing difficulties if inhaled, may cause allergy or asthma symptoms or breathing difficulties if,... The like such as a technical grade mixture of isomers produced by the condensation / addition reaction of an and... The most widely used in a mixture with other solvents and chemicals such as paint pigments toluene or...: diphenylmethane diisocyanate ( TDI ) ( 3 ) ( 4 ), such as paint.... ) Risk assessment outcomes: harmful if inhaled, may cause allergic respiratory such... Revision Number 2 1 réalisée par Bolognesi et al C & L.! Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; potentially Incompatible Absorbents Toluene-2,6-Diisocyanate affects reproduction urea, semicarbazide biuret! Reproductive Hazard * there is no safe level of exposure to a carcinogen, Colorless liquid becomes... 6 H 3 ( NCO ) 2 impose a significant Health Hazard solid or liquid ( above 71°F with! Hdi ) are useful for polyurethane products as paint pigments: toluene CAS-No tolylene-2,4-diisocyanate %! Protective measures, urea, semicarbazide, biuret, and the toluene diisocyanate hazards diisocyanate is Extremely toxic acute. Useful for polyurethane products organs: eyes, skin, respiratory tract pungent odor acute exposure a. Ghs information provided by 1196 companies screening assessment conclusions ; preventive actions and Risk!